Lions Mane
Hericium erinaceus
Lion’s Mane contains over 70 bioactive compounds. There are several metabolites which have been identified and isolated that hold great potential for nerve and brain health. Of particular interest are hericenones and erinacines, which are believed to occur only in Hericium spp. Hericenones are isolated from Lion's mane fruiting bodies, and erinacines are isolated from the mycelium. Both hericenones and erinacines are low molecular weight compounds that potentially cross the blood–brain barrier.
Alternative names:
Yamabushitake (mountain priest mushroom) in Japanese. In Vietnamese and Chinese, hóu tóu gû (monkey head). Also known as Pom-Pom mushroom, satyr's beard, bearded tooth mushroom, bearded hedgehog mushroom, or bearded tooth fungus.
Above picture: Lion's Mane mushroom in wild
Key Actions:
- Anti-hyperglycaemic
- Anti-inflammatory
- Antioxidant
- Anti-ulcerative
- Anxiolytic
- Antidepressant
- Gastrointestinoprotective
- Immunomodulatory
- Lipid-modulatory
- Neuroprotective & neutrophic
- Nootropic
- Probiotic
Key Indications:
- Alzheimer’s disease
- Anxiety
- Cognitive decline & dementia
- Depression
- Diabetes and metabolic syndrome
- Dysbiosis
- Epilepsy
- Gastric & peptic ulceration
- Inflammatory bowel disease
- Insomnia and sleep disorders
- Multiple sclerosis
- Neurodegenerative disease
- Neuropathy
Key active compounds:
Polysaccharides (Beta glucans, Alpha glucans, Galactans, Fucans, Heteroglycans, Glycoproteins)
Terpenoids - Hericenones A-K, O-R), Erinacines (A-K, P, Q, S-V, Z1
Polyphenols
Sterols
History
Lion’s mane is a mushroom with a history of both medicinal and culinary uses in Asia and Europe. Medicinal mushroom use dates back to 450 BCE when Greek physician Hippocrates discovered the potential anti-inflammatory properties of fungi as well as its role in wound cauterization.
EXTRACTION METHOD:
- Fruiting body - Lossless hot water extraction
- Mycelium - Hot water + alcohol extraction
Interactions with pharmaceuticals
Interactions with herbs & supplements
Chinese Medicine Perspective
Geographic location
Lion’s mane mushroom grows most commonly on decaying hardwood in forests across North America, Asia and Europe.
Based on traditional use it appears endemic to China and Japan.
Edibility
Lion’s Mane can be enjoyed as a culinary mushroom when cooked. It can be sautéd with olive oil, salt, pepper, and perhaps white wine, or substied for crab or lobster pieces in recipes as its texture and taste is quite similar.
Research articles
- "H. erinaceus may supply neuroprotective metabolites to be used as valuable, effective candidates for treating and preventing age-related neurodegenerative diseases." (2021) Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
- "The extracts thus could be used to treat oxidative stress-related disorders as they are found to contain antioxidant compounds like phenols and others and also they possessed good antimicrobial and anticancer activity." (2021) Prospecting medicinal properties of Lion's mane mushroom
- "In particular, they seem to act on microglia and consequently on the NF-κB pathway, reducing the neuroinflammation that spreads from the cortex to other areas of the brain." (2021) Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury
- "In conclusion, our study showed that 4 weeks of intraperitoneal administration of HE alleviated depressive-like behaviours in a CRS model of depression." (2021) Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression
- "...a significant improvement in Mini-Mental State Examination score was observed in the EAHE group and a significant Instrumental Activities of Daily Living score difference were found between the two groups." (2020) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study
- "The pre-clinical and clinical studies have demonstrated that H. erinaceussignificantly ameliorates depressive disorder through monoaminergic modulation, neurogenic/neurotrophic, and anti-inflammatory pathway. (2019) Therapeutic Potential of Hericium erinaceus for Depressive Disorder
- We speculate that various chemical compounds, including hericenones, in the mushroom have multiple effects to the brain neural networks and improve cognitive functions. Oral intake of H.erinaceus is safe and convenient method for dementia prevention so far. (2019) Improvement of cognitive functions by oral intake of Hericium erinaceus
- "The mechanisms of neuroprotection were through the improvement of antioxidant, mitochondrial function and anti-apoptosis." (2019) Lion’s Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia
- "...the majority of preclinical data strongly suggests that it is safe and offers much-needed neuroprotective applications." (2018) Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
- "Over the past decade, it has been demonstrated that H. erinaceus polysaccharides possess various promising bioactivities, including antitumor and immunomodulation, anti-gastric ulcer, neuroprotection and neuroregeneration, anti-oxidation and hepatoprotection, anti-hyperlipidemia, anti-hyperglycemia, anti-fatigue and anti-aging." (2017) Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review
- "The reported health-promoting properties of the mushroom fruit bodies, mycelia, and bioactive pure compounds include antibiotic, anticarcinogenic, antidiabetic, antifatigue, antihypertensive, antihyperlipodemic, antisenescence, cardioprotective, hepatoprotective, nephroprotective, and neuroprotective properties and improvement of anxiety, cognitive function, and depression." (2015) Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds
- "hericenone B had a strong anti-platelet activity and it might be a novel compound for antithrombotic therapy possessing a novel mechanism." (2010) Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation
- Hericium erinaceus- an edible mushroom with medicinal values
- Effects of cultivation techniques and processing on antimicrobial and antioxidant activities of Hericium erinaceus
- Compounds for dementia from Hericium erinaceum
- Reversal of cognitive decline: A novel therapeutic program
- Hericenones and erinacines- stimulators of nerve growth factor (NGF) biosynthesis in Hericium erinaceus
- Reduction of depression and anxiety after 4 weeks of Lion's Mane intake
- Functional Recovery Enhancement Following Injury to Rodent Peroneal Nerve by Lion’s Mane Mushroom, Hericium erinaceus
- Hypoglycemic effect of extract of Hericium erinaceus
- The influence of Hericium erinaceus extract on myelination process in vitro
- Protective Effects of Hericium erinaceus Mycelium and Its Isolated Erinacine A against Ischemia-Injury-Induced Neuronal Cell Death
- Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress
- Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies
- Cyanthin Diterpenoid and Sesterterpene Constituents of Hericium erinaceus Mycelium Ameliorate Alzheimer’s Disease-Related Pathologies
- Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain
- "H. erinaceus may supply neuroprotective metabolites to be used as valuable, effective candidates for treating and preventing age-related neurodegenerative diseases." (2021) Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
Mushroom Education Project 2024